Biotinylated Peptides – A Key Ingredient in BM Skin Care
BM skin care helps prevent ageing and regenerates your complexion for a fresher and healthier-looking appearance. It also contains antioxidants to protect your skin from the sun and a rich blend of oils to nourish it.
In a double-blind study, researchers found that microbiome-supporting skin care products improved the microbiome and biophysical skin parameters. Specifically, these products increased the expression of BM proteins and laminin protein.
Biotinylated peptides
Biotinylated peptides are used in various cosmeceutical products. Their unique ability to mimic natural amino acids allows them to bind and interact with the targeted proteins or macromolecules. This interaction provides the target molecule with functional groups that can enhance its biological activity. The use of peptides as a biological tool is increasing in cosmeceutical applications, but the production of these molecules can be a costly and labor-intensive process. However, biotinylation reagents can help reduce the cost and time required for synthesis.
During the last decade, a number of scientific studies have supported the claimed biological activity of biotinylated peptides as cosmetic ingredients. These studies indicate that the biotinylated peptides exhibit anti-wrinkle properties and can improve skin appearance. However, the research on these cosmeceutical ingredients is ongoing and requires further investigations.
The recently identified role of the dermal-epidermal junction (DEJ) in skin aging has suggested an alternative anti-wrinkle mechanism. The DEJ is a biological interface between the epidermis and dermis, providing physical adherence and molecular transport. It is composed of basement membrane proteins, including laminins and heparin sulfate proteoglycans.
In this study, three peptides that stimulated protein aesthetic skin care expression of the DEJ in cultured human epidermal keratinocytes were combined into a peptide complex and tested for their anti-aging effects. The peptide complex significantly increased protein expressions of collagen XVII, laminin, and nidogen in cultured skin cells. The peptide complex also enhanced nidogen and laminin expression in ex vivo human skin tissue.
Peptides complex
Peptides are a key ingredient in many anti-aging skin care products. They can be used to increase collagen production and help smooth fine lines and wrinkles. They can also be used to prevent sun damage and even out skin tone. They can also help prevent the breakdown of elastin fibers, making skin look firmer and more taut.
The peptide complex is a blend of active peptides that can be applied topically to improve skin texture and firmness. It aesthetic skin care shop has a high concentration of copper tripeptide growth factor and a 15% concentration of L-ascorbic acid (vitamin C). The formulation is free of fragrance, sulfates and parabens.
In a recent clinical study, the peptide complex showed that it can reduce skin wrinkles by increasing the expression of the basement membrane proteins laminin 522 and collagen XVII. In addition, it also increased the expression of nidogen and heparin sulfate proteoglycans, which are the other main constituents of the dermal-epidermal junction (DEJ).
The peptide complex contains a patented balance of bioavailable anti-aging tetrapeptides, hyaluronic acid and sea fern extract. It is formulated in France on a certified site that adheres to good manufacturing practices. It is also non-sensitizing, non-photogenic and non-mutagenic. It is an excellent product for all skin types, especially mature and dehydrated skin. It can be used with a moisturizing serum or as a daily face cream.
Anti-wrinkle activity
Bm Regenerate Anti Ageing Serum is a powerful serum that promotes skin regeneration, protecting from environmental aggressors. Its formula with a high concentration of glycolic acid is combined with the powerful antioxidant Ubiquinone. It reduces wrinkles, blemishes and redness of the skin while visibly improving skin tone. It is suitable for dry, mature or premature ageing skins as well as for skins concerned with preventative ageing.
The basement membrane (BM) is an important structure that provides both physical adherence and supports molecular transport. Its major proteins are laminins, collagen IV and nidogens. A decreased expression of BM proteins is associated with the development of senescent fibroblasts and wrinkles. Stimulation of the BM proteins by peptides has been demonstrated to increase epidermal protein expression and improve skin wrinkles.
We have developed a series of peptides that target BM proteins by modulating their expression. These peptides are conjugated with vitamin C using the ascorbyl succinyl group and have been shown to induce epidermal protein expression in vitro. Several in vivo and ex vivo studies have demonstrated that the peptides have anti-wrinkle activity in humans. They also enhance skin elasticity, firmness and hydration and improve the appearance of fine lines and wrinkles.
